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Published online
doi:10.1083/jcb.200709152
The Journal of Cell Biology, Vol. 179, No. 2, 179-181
The Rockefeller University Press, 0021-9525 $30.00
© Compton
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Chromosome orientation



Duane A. Compton

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755

Correspondence to Duane A. Compton: Duane.a.compton{at}dartmouth.edu

Precise chromosome segregation during cell division results from the attachment of chromosomes to microtubules emanating from both poles of the spindle apparatus. The molecular machinery involved in establishing and maintaining properly oriented microtubule attachments remains murky. Some clarity is now emerging with the identification of Bod1 (Biorientation Defective 1), a protein that promotes chromosome biorientation by unleashing chromosomes from improperly oriented microtubule attachments.


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