DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

doi:10.1083/jcb.200705106

Published online
doi:10.1083/jcb.200705106
The Journal of Cell Biology, Vol. 179, No. 2, 183-186
The Rockefeller University Press, 0021-9525 $30.00
© Weterings et al.

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DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Eric Weterings and David J. Chen

Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390

Correspondence to David J. Chen: david.chen{at}utsouthwestern.edu

The DNA-dependent protein kinase (DNA-PK) is one of the centralenzymes involved in DNA double-strand break (DSB) repair. Itfacilitates proper alignment of the two ends of the broken DNAmolecule and coordinates access of other factors to the repaircomplex. We discuss the latest findings on DNA-PK phosphorylationand offer a working model for the regulation of DNA-PK duringDSB repair.

Abbreviations used in this paper: ATM, ataxia telangiectasiamutated; ATR, ataxia telangiectasia related protein; DSB, double-strandbreak; HR, homologous recombination; NHEJ, nonhomologous endjoining.

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