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Published online
doi:10.1083/jcb.200710156
The Journal of Cell Biology, Vol. 179, No. 4, 583-584
The Rockefeller University Press, 0021-9525 $30.00
© Huber et al.
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The size-wise nucleus: nuclear volume control in eukaryotes



Michael D. Huber and Larry Gerace

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037

Correspondence to Larry Gerace: lgerace{at}scripps.edu

Eukaryotic cells have an "awareness" of their volume and organellar volumes, and maintain a nuclear size that is proportional to the total cell size. New studies in budding and fission yeast have examined the relationship between cell and nuclear volumes. It was found that the size of the nucleus remains proportional to cell size in a wide range of genetic backgrounds and growth conditions that alter cell volume and DNA content. Moreover, in multinucleated fission yeast cells, Neumann and Nurse (see p. 593 of this issue) found that the sizes of individual nuclei are controlled by the relative amount of cytoplasm surrounding each nucleus. These results highlight a role of the cytoplasm in nuclear size control.

Abbreviations used in this paper: N/C, nuclear/cell; NE, nuclear envelope.


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