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Plasmid segregation: spatial awareness at the molecular level

¹ Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark
² Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE1 7RU, England, UK

Correspondence to Jakob Møller-Jensen: jakobm{at}bmb.sdu.dk

In bacteria, low-copy number plasmids ensure their stable inheritance by partition loci (par), which actively distribute plasmid replicates to each side of the cell division plane. Using time-lapse fluorescence microscopic tracking of segregating plasmid molecules, a new study provides novel insight into the workings of the par system from Escherichia coli plasmid R1. Despite its relative simplicity, the plasmid partition spindle shares characteristics with the mitotic machinery of eukaryotic cells.

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