Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1461K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Thompson, S. L. Articles by Compton, D. A. Search for Related Content PubMed PubMed Citation Articles by Thompson, S. L. Articles by Compton, D. A. Pubmed/NCBI databases Medline Plus Health Information Cancer Related Collections Related Article Related In this Issue article Social Bookmarking                            What's this?

Examining the link between chromosomal instability and aneuploidy in human cells

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755

Correspondence to Duane A. Compton: duane.a.compton{at}dartmouth.edu

Solid tumors can be highly aneuploid and many display high rates of chromosome missegregation in a phenomenon called chromosomal instability (CIN). In principle, aneuploidy is the consequence of CIN, but the relationship between CIN and aneuploidy has not been clearly defined. In this study, we use live cell imaging and clonal cell analyses to evaluate the fidelity of chromosome segregation in chromosomally stable and unstable human cells. We show that improper microtubule–chromosome attachment (merotely) is a cause of chromosome missegregation in unstable cells and that increasing chromosome missegregation rates by elevating merotely during consecutive mitoses generates CIN in otherwise stable, near-diploid cells. However, chromosome missegregation compromises the proliferation of diploid cells, indicating that phenotypic changes that permit the propagation of nondiploid cells must combine with elevated chromosome missegregation rates to generate aneuploid cells with CIN.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

Related Article

The wages of CIN

Karen W. Yuen and Arshad Desai
J. Cell Biol. 2008 180: 661-663. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Janssen, A., Kops, G. J. P. L., Medema, R. H. (2009). Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc. Natl. Acad. Sci. USA 106: 19108-19113 [Abstract] [Full Text]  
• Courtheoux, T., Gay, G., Gachet, Y., Tournier, S. (2009). Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast. JCB 187: 399-412 [Abstract] [Full Text]  
• Torosantucci, L., De Santis Puzzonia, M., Cenciarelli, C., Rens, W., Degrassi, F. (2009). Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes. J. Cell Sci. 122: 3455-3461 [Abstract] [Full Text]  
• Liu, J., Wang, Z., Jiang, K., Zhang, L., Zhao, L., Hua, S., Yan, F., Yang, Y., Wang, D., Fu, C., Ding, X., Guo, Z., Yao, X. (2009). PRC1 Cooperates with CLASP1 to Organize Central Spindle Plasticity in Mitosis. J. Biol. Chem. 284: 23059-23071 [Abstract] [Full Text]  
• Williams, B. R., Amon, A. (2009). Aneuploidy: Cancer's Fatal Flaw?. Cancer Res. 69: 5289-5291 [Abstract] [Full Text]  
• Weaver, B. A.A., Cleveland, D. W. (2009). The role of aneuploidy in promoting and suppressing tumors. JCB 185: 935-937 [Abstract] [Full Text]  
• Zhang, J., Neisa, R., Mao, Y. (2009). Oncogenic Adenomatous Polyposis Coli Mutants Impair the Mitotic Checkpoint through Direct Interaction with Mad2. Mol. Biol. Cell 20: 2381-2388 [Abstract] [Full Text]  
• Orth, J. D., Tang, Y., Shi, J., Loy, C. T., Amendt, C., Wilm, C., Zenke, F. T., Mitchison, T. J. (2008). Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Molecular Cancer Therapeutics 7: 3480-3489 [Abstract] [Full Text]  
• Torres, E. M., Williams, B. R., Amon, A. (2008). Aneuploidy: Cells Losing Their Balance. Genetics 179: 737-746 [Abstract] [Full Text]  
• Yuen, K. W., Desai, A. (2008). The wages of CIN. JCB 180: 661-663 [Abstract] [Full Text]  
• LeBrasseur, N. (2008). Losing odd chromosomes. JCB 180: 649-649 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents