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Published online
doi:10.1083/jcb.200802062
The Journal of Cell Biology, Vol. 180, No. 5, 853-855
The Rockefeller University Press, 0021-9525 $30.00
© Cai et al.
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Peering deeply inside the branch



Liang Cai1,2 and James E. Bear1,2

1 Lineberger Comprehensive Cancer Center and 2 Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Correspondence to James E. Bear: jbear{at}email.unc.edu

The actin-related protein 2/3 (Arp2/3) story has captivated the cytoskeleton community for over a decade. Not only does this complex nucleate new actin filaments, but it also anchors them into a dendritic meshwork that is used in many cellular contexts such as lamellipodial protrusion, endosome rocketing, and the movement of pathogens. One key piece of this puzzle that has been missing is a detailed structure of the Arp2/3-actin branch. Using electron tomography and computational docking, Rouiller et al. (Rouiller, I., X.-P. Xu, K.J. Amann, C. Egile, S. Nickell, D. Nicastro, R. Li, T.D. Pollard, N. Volkmann, and D. Hanein. 2008. J. Cell Biol. 180:887–895) present an elegant and intriguing structure of the Arp2/3 complex–mediated actin branch.


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Related Article

The structural basis of actin filament branching by the Arp2/3 complex
Isabelle Rouiller, Xiao-Ping Xu, Kurt J. Amann, Coumaran Egile, Stephan Nickell, Daniela Nicastro, Rong Li, Thomas D. Pollard, Niels Volkmann, and Dorit Hanein
J. Cell Biol. 2008 180: 887-895. [Abstract] [Full Text] [PDF]





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