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Published online April 14, 2008
doi:10.1083/jcb.200712054
The Journal of Cell Biology, Vol. 181, No. 2, 189-194
The Rockefeller University Press, 0021-9525 $30.00
© 2008 von Roretz et al.
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Decoding ARE-mediated decay: is microRNA part of the equation?



Christopher von Roretz and Imed-Eddine Gallouzi

Biochemistry Department, McGill University, Montreal, Canada H3G 1Y6

Correspondence to Imed-Eddine Gallouzi: imed.gallouzi{at}mcgill.ca

Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3' untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.

Abbreviations used in this paper: AGO, Argonaute; AMD, ARE-mediated decay; ARE, adenine/uridine-rich element; AUBP, ARE binding protein; FXR1, fragile X mental retardation–related protein 1; miRNA, microRNA; miRNP, microRNP; PB, processing body; SG, stress granule; TTP, tristetraprolin.


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