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Published online
doi:10.1083/jcb.200802081
The Journal of Cell Biology, Vol. 181, No. 6, 879-884
The Rockefeller University Press, 0021-9525 $30.00
© Fackler et al.
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Cell motility through plasma membrane blebbing



Oliver T. Fackler1 and Robert Grosse2

1 Department of Virology and 2 Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany

Correspondence to Oliver T. Fackler: oliver.fackler{at}med.uni-heidelberg.de; or Robert Grosse: robert.grosse{at}pharma.uni-heidelberg.de

Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction.

Abbreviations used in this paper: GPCR, G protein–coupled receptor; PM, plasma membrane; ROCK, Rho-associated kinase.

© 2008 Fackler and Grosse This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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