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Published online
doi:10.1083/jcb.200805110
The Journal of Cell Biology, Vol. 182, No. 1, 11-13
The Rockefeller University Press, 0021-9525 $30.00
© Meldolesi
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Inhibition of adipogenesis: a new job for the ER Ca2+ pool



Jacopo Meldolesi

Vita-Salute San Raffaele University and San Raffaele Institute, 20132 Milan, Italy

Correspondence to Jacopo Meldolesi: meldolesi.jacopo{at}hsr.it

Adipogenesis is the process of differentiation of adipocytes from mesenchymal multipotent cells through adipocyte precursors. In this issue, a study by the groups of Opas and Michalak (Szabo, E., Y. Qiu, S. Baksh, M. Michalak, and M. Opas. 2008. J. Cell. Biol. 182:103–116) demonstrates that this process is repressed by increasing intracellular Ca2+, which, in turn, is dependent on the expression of calreticulin, the major Ca2+-binding protein of the endoplasmic reticulum lumen.

© 2008 Meldolesi This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Calreticulin inhibits commitment to adipocyte differentiation
Eva Szabo, Yuanyuan Qiu, Shairaz Baksh, Marek Michalak, and Michal Opas
J. Cell Biol. 2008 182: 103-116. [Abstract] [Full Text] [PDF]





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