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Published online
doi:10.1083/jcb.200804157
The Journal of Cell Biology, Vol. 182, No. 2, 225-232
The Rockefeller University Press, 0021-9525 $30.00
© Hegde et al.
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The concept of translocational regulation



Ramanujan S. Hegde and Sang-Wook Kang

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

Correspondence to Ramanujan S. Hegde: hegder{at}mail.nih.gov

Biological processes are regulated to provide cells with exquisite adaptability to changing environmental conditions and cellular demands. The mechanisms regulating secretory and membrane protein translocation into the endoplasmic reticulum (ER) are unknown. A conceptual framework for translocational regulation is proposed based on our current mechanistic understanding of ER protein translocation and general principles of regulatory control.

Abbreviations used in this paper: RNC, ribosome-nascent chain complex; SR, SRP receptor; SRP, signal recognition particle; TMD, transmembrane domain; TRAM, translocating chain-associating membrane protein; TRAP, translocon-associated protein complex.


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