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Published online
doi:10.1083/jcb.200807093
The Journal of Cell Biology, Vol. 182, No. 3, 417-419
The Rockefeller University Press, 0021-9525 $30.00
© Tomishige
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Activation of mitotic kinesin by microtubule bundling



Michio Tomishige

Department of Applied Physics, The University of Tokyo, Tokyo 113-8656, Japan

Correspondence to Michio Tomishige: tomishige{at}ap.t.u-tokyo.ac.jp

Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421–428) demonstrate that microtubule cross-linking triggers the conversion of kinesin-5 motility from a diffusive mode to a directional mode, initiating antiparallel microtubule sliding.

© 2008 Tomishige This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Microtubule cross-linking triggers the directional motility of kinesin-5
Lukas C. Kapitein, Benjamin H. Kwok, Joshua S. Weinger, Christoph F. Schmidt, Tarun M. Kapoor, and Erwin J.G. Peterman
J. Cell Biol. 2008 182: 421-428. [Abstract] [Full Text] [PDF]





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