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Published online August 25, 2008
doi:10.1083/jcb.200807061
The Journal of Cell Biology, Vol. 182, No. 4, 621-622
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Simonsen et al.
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Self-eating from an ER-associated cup



Anne Simonsen and Harald Stenmark

Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, and Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway

Correspondence to Harald Stenmark: stenmark{at}ulrik.uio.no

Since the first morphological description of autophagosomes in the early 1960s, two critical questions have been a matter of intense investigation and debate: what is the origin of the autophagosomal membrane and how is it formed? A study by Axe et al. (E.L. Axe, S.A. Walker, M. Manifava, P. Chandra, H.L. Roderick, A. Habermann, G. Griffiths, and N.T. Ktistakis. 2008. J. Cell Biol. 182:685–701) provides evidence that cup-shaped protrusions from the endoplasmic reticulum, named omegasomes, serve as platforms for autophagosome biogenesis in mammalian cells.

Abbreviations used in this paper: Atg, autophagy-related; DFCP1, double FYVE domain–containing protein 1; PI3P, phosphatidylinositol 3-phosphate; Vps, vacuolar protein sorting.

© 2008 Simonsen and Stenmark This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe, Simon A. Walker, Maria Manifava, Priya Chandra, H. Llewelyn Roderick, Anja Habermann, Gareth Griffiths, and Nicholas T. Ktistakis
J. Cell Biol. 2008 182: 685-701. [Abstract] [Full Text] [PDF]





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