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Published online August 25, 2008
doi:10.1083/jcb.200710141
The Journal of Cell Biology, Vol. 182, No. 4, 801-815
The Rockefeller University Press, 0021-9525 $30.00
© 2008 O'Reilly et al.
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Article

 Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary

Alana M. O'Reilly1, Hsiu-Hsiang Lee2, and Michael A. Simon1

1 Department of Biological Sciences, Stanford University, Stanford, CA 94305
2 Department of Physiology, University of California, San Francisco, San Francisco, CA 94143

Correspondence to Michael A. Simon: msimon{at}stanford.edu

Adult stem cells are maintained in specialized microenvironments called niches, which promote self-renewal and prevent differentiation. In this study, we show that follicle stem cells (FSCs) in the Drosophila melanogaster ovary rely on cues that are distinct from those of other ovarian stem cells to establish and maintain their unique niche. We demonstrate that integrins anchor FSCs to the basal lamina, enabling FSCs to maintain their characteristic morphology and position. Integrin-mediated FSC anchoring is also essential for proper development of differentiating prefollicle cells that arise from asymmetrical FSC divisions. Our results support a model in which FSCs contribute to the formation and maintenance of their own niche by producing the integrin ligand, laminin A (LanA). Together, LanA and integrins control FSC proliferation rates, a role that is separable from their function in FSC anchoring. Importantly, LanA-integrin function is not required to maintain other ovarian stem cell populations, demonstrating that distinct pathways regulate niche–stem cell communication within the same organ.

A.M. O'Reilly's present address is Fox Chase Cancer Center, Philadelphia, PA 19111.

Abbreviations used in this paper: ACI, after clone induction; ESC, escort stem cell; FSC, follicle stem cell; GSC, germline stem cell; LanA, laminin A; WT, wild type.

© 2008 O'Reilly et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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