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Published online
doi:10.1083/jcb.200808121
The Journal of Cell Biology, Vol. 182, No. 6, 1035-1038
The Rockefeller University Press, 0021-9525 $30.00
© Lawrence et al.
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Gene associations: true romance or chance meeting in a nuclear neighborhood?



Jeanne B. Lawrence and Christine M. Clemson

Department of Cell Biology, University of Massachusetts Medical Center, Worcester, MA 01655

Correspondence to Jeanne B. Lawrence: Jeanne.Lawrence{at}umassmed.edu

Many recent studies have raised interest in the nuclear associations of coregulated genes from different chromosomes, often evoking interpretations of gene–gene interactions, communication, and even "romance." However, in some cases, the associations may be indirect and infrequent and may reflect the segregation of active and inactive genes into different nuclear compartments. The study by Brown et al. (see p. 1083 of this issue) reports that the apparent association of erythroid genes is not a direct interaction nor colocalization to one tiny transcription factory but arises as a result of the known clustering of many active genes with larger splicing factor–rich speckles (a.k.a., SC35-defined domains). This clustering appears largely stochastic but is impacted by the chromosomal neighborhood of the gene as well as its transcriptional status. The study adds a new twist by examining the same gene in a foreign chromosomal context, providing evidence that this impacts a gene's propensity to form gene–domain (or apparent gene–gene) associations within nuclei.

© 2008 Lawrence and Clemson This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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