JCB logo
ReproCELL
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online October 6, 2008
doi:10.1083/jcb.200809056
The Journal of Cell Biology, Vol. 183, No. 1, 7-9
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Filippi et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 726K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Filippi, B. M.
Right arrow Articles by Alessi, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Filippi, B. M.
Right arrow Articles by Alessi, D. R.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Comment

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters



Beatrice Maria Filippi and Dario R. Alessi

Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK

Correspondence to Beatrice M. Filippi: b.filippi{at}dundee.ac.uk; or Dario R. Alessi: d.r.alessi{at}dundee.ac.uk

A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11–17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.

© 2008 Filippi and Alessi This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster
Cholsoon Jang, Gina Lee, and Jongkyeong Chung
J. Cell Biol. 2008 183: 11-17. [Abstract] [Full Text] [PDF]





  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents