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Published online
doi:10.1083/jcb.200809056
The Journal of Cell Biology, Vol. 183, No. 1, 7-9
The Rockefeller University Press, 0021-9525 $30.00
© Filippi et al.
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Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters



Beatrice Maria Filippi and Dario R. Alessi

Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK

Correspondence to Beatrice M. Filippi: b.filippi{at}dundee.ac.uk; or Dario R. Alessi: d.r.alessi{at}dundee.ac.uk

A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11–17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.

© 2008 Filippi and Alessi This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster
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J. Cell Biol. 2008 183: 11-17. [Abstract] [Full Text] [PDF]





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