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16th INTERNATIONAL VASCULAR BIOLOGY MEETING
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Published online
doi:10.1083/jcb.200810040
The Journal of Cell Biology, Vol. 183, No. 3, 371-373
The Rockefeller University Press, 0021-9525 $30.00
© Polakis
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Formation of the blood–brain barrier: Wnt signaling seals the deal



Paul Polakis

Genentech, Inc., South San Francisco, CA 94080

Correspondence to Paul Polakis: ppolakis{at}gene.com

Capillaries in the brain are especially selective in determining which blood-borne components gain access to neurons. The structural elements of this blood–brain barrier (BBB) reside at the tight junction, an intercellular protein complex that welds together adjacent endothelial cell membranes in the microvasculature. In this issue, Liebner et al. (Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. J. Cell Biol. 183: 409–417) report that Wnt signaling plays an active role in the development of the BBB by regulating expression of key protein constituents of the tight junction. Such mechanistic insight has implications for a variety of neuropathological states in which the BBB is breached.

© 2008 Polakis This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Wnt/β-catenin signaling controls development of the blood–brain barrier
Stefan Liebner, Monica Corada, Thorsten Bangsow, Jane Babbage, Andrea Taddei, Cathrin J. Czupalla, Marco Reis, Angelina Felici, Hartwig Wolburg, Marcus Fruttiger, Makoto M. Taketo, Harald von Melchner, Karl Heinz Plate, Holger Gerhardt, and Elisabetta Dejana
J. Cell Biol. 2008 183: 409-417. [Abstract] [Full Text] [PDF]





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