JCB logo
Accuri Cytometers
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online November 3, 2008
doi:10.1083/jcb.200809173
The Journal of Cell Biology, Vol. 183, No. 3, 375-376
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Ley et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 575K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ley, K.
Right arrow Articles by Zhang, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ley, K.
Right arrow Articles by Zhang, H.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Comment

Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms



Klaus Ley and Hong Zhang

Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037

Correspondence to Klaus Ley: klaus{at}liai.org

Rather than just providing an unstructured adhesive surface for leukocytes, cytokine-activated endothelial cells assemble preexisting tetraspanin-enriched microdomains to form endothelial adhesive platforms (EAPs) and endothelial docking structures. In this issue of the Journal of Cell Biology, Barreiro et al. (Barreiro, O., M. Zamai, M. Yáñez-Mó, E. Tejera, P. López-Romero, P.N. Monk, E. Gratton, V.R. Caiolfa, and F. Sánchez-Madrid. 2008. J. Cell Biol. 183:527–542) show how the immunoglobulin superfamily adhesion molecules intercellular adhesion molecule (ICAM)–1 and vascular cell adhesion molecule (VCAM)–1 form nanoclusters with the tetraspanins CD9 and CD151 in a physiologically relevant system. Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts.

© 2008 Ley and Zhang This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms
Olga Barreiro, Moreno Zamai, María Yáñez-Mó, Emilio Tejera, Pedro López-Romero, Peter N. Monk, Enrico Gratton, Valeria R. Caiolfa, and Francisco Sánchez-Madrid
J. Cell Biol. 2008 183: 527-542. [Abstract] [Full Text] [PDF]





  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents