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Published online
doi:10.1083/jcb.200811057
The Journal of Cell Biology, Vol. 183, No. 6, 971-974
The Rockefeller University Press, 0021-9525 $30.00
© Duncan et al.
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Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart



Mara C. Duncan1 and Mark Peifer1,2

1 Department of Biology, and 2 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Correspondence to Mark Peifer: peifer{at}unc.edu

The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. Cdc42 is a well-known regulator of the actin cytoskeleton, but also plays important roles in vesicular trafficking. In this issue, Harris and Tepass (Harris, K.P, and U. Tepass. 2008. J. Cell. Biol. 183:1129–1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins.

© 2008 Duncan and Peifer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis
Kathryn P. Harris and Ulrich Tepass
J. Cell Biol. 2008 183: 1129-1143. [Abstract] [Full Text] [PDF]



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