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Published online
doi:10.1083/jcb.200811086
The Journal of Cell Biology, Vol. 183, No. 6, 975-977
The Rockefeller University Press, 0021-9525 $30.00
© Rasband
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Na+ channels get anchored...with a little help



Matthew N. Rasband

Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030

Correspondence to Matthew N. Rasband: rasband{at}bcm.edu

Neurons have high densities of voltage-gated Na+ channels that are restricted to axon initial segments and nodes of Ranvier, where they are responsible for initiating and propagating action potentials. New findings (Bréchet, A., M.-P. Fache, A. Brachet, G. Ferracci, A. Baude, M. Irondelle, S. Pereira, C. Leterrier, and B. Dargent. 2008. J. Cell Biol. 183:1101–1114) reveal that phosphorylation of several key serine residues by the protein kinase CK2 regulates Na+ channel interactions with ankyrin G. The presence of CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the specific accumulation and retention of Na+ channels within these important domains.

© 2008 Rasband This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G
Aline Bréchet, Marie-Pierre Fache, Anna Brachet, Géraldine Ferracci, Agnés Baude, Marie Irondelle, Sandrine Pereira, Christophe Leterrier, and Bénédicte Dargent
J. Cell Biol. 2008 183: 1101-1114. [Abstract] [Full Text] [PDF]





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