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Published online December 22, 2008
doi:10.1083/jcb.200811136
The Journal of Cell Biology, Vol. 183, No. 7, 1183-1185
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Wittmann
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EBs clip CLIPs to growing microtubule ends



Torsten Wittmann

Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143

Correspondence to Torsten Wittmann: torsten.wittmann{at}ucsf.edu

Proteins that track growing microtubule (MT) ends are important for many aspects of intracellular MT function, but the mechanism by which these +TIPs accumulate at MT ends has been the subject of a long-standing controversy. In this issue, Bieling et al. (Bieling, P., S. Kandels-Lewis, I.A. Telley, J. van Dijk, C. Janke, and T. Surrey. 2008. J. Cell Biol. 183:1223–1233) reconstitute plus end tracking of EB1 and CLIP-170 in vitro, which demonstrates that CLIP-170 plus end tracking is EB1-dependent and that both +TIPs rapidly exchange between a soluble and a plus end–associated pool. This strongly supports the hypothesis that plus end tracking depends on a biochemical property of growing MT ends, and that the characteristic +TIP comets result from the generation of new +TIP binding sites through MT polymerization in combination with the exponential decay of these binding sites.

© 2008 Wittmann This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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Related Article

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites
Peter Bieling, Stefanie Kandels-Lewis, Ivo A. Telley, Juliette van Dijk, Carsten Janke, and Thomas Surrey
J. Cell Biol. 2008 183: 1223-1233. [Abstract] [Full Text] [PDF]



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