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Published online
doi:10.1083/jcb.200810038
The Journal of Cell Biology, Vol. 183, No. 7, 1187-1191
The Rockefeller University Press, 0021-9525 $30.00
© Belting et al.
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Nanotubes, exosomes, and nucleic acid–binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease



Mattias Belting and Anders Wittrup

Lund University, Department of Clinical Sciences, Section of Oncology, Barngatan 2:1, SE-221 85 Lund, Sweden

Correspondence to Mattias Belting: mattias.belting{at}med.lu.se

The prevailing view that eukaryotic cells are restrained from intercellular exchange of genetic information has been challenged by recent reports on nanotubes, exosomes, apoptotic bodies, and nucleic acid–binding peptides that provide novel pathways for cell–cell communication, with implications in health and disease.

Abbreviations used in this paper: dsRNA, double-stranded RNA; miRNA, microRNA; RdRP, RNA-dependent RNA polymerase; TNT, tunneling nanotube.

© 2008 Belting and Wittrup This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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