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Published online
doi:10.1083/jcb.200812016
The Journal of Cell Biology, Vol. 184, No. 3, 355-356
The Rockefeller University Press, 0021-9525 $30.00
© McEwen et al.
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Releasing the spindle assembly checkpoint without tension



Bruce F. McEwen and Yimin Dong

Wadsworth Center, New York State Department of Health, Albany, NY 12201

Correspondence to Bruce F. McEwen: bruce.mcewen{at}wadsworth.org

Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase onset, the events triggering SAC release are poorly understood. Papers in this issue by Uchida et al. (Uchida, K.S.K., K. Takagaki, K. Kumada, Y. Hirayama, T. Noda, and T. Hirota. 2009. J. Cell Biol. 184:383–390) and Maresca and Salmon (Maresca, T.J., and E.D. Salmon. 2009. J. Cell Biol. 184:373–381) make an important advance by demonstrating that SAC release depends on molecular rearrangements within the kinetochore rather than tension-produced stretch between sister kinetochores.

© 2009 McEwen and Dong
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