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Published online
doi:10.1083/jcb.200811141
The Journal of Cell Biology, Vol. 184, No. 5, 621-629
The Rockefeller University Press, 0021-9525 $30.00
© Tien et al.
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A Notch updated



An-Chi Tien1, Akhila Rajan2, and Hugo J. Bellen1,2,3,4

1 Program in Developmental Biology, 2 Department of Molecular and Human Genetics, 3 Department of Neuroscience, and 4 Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030

Correspondence to H.J. Bellen: hbellen{at}bcm.tmc.edu

Cell–cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifications in the extracellular domain as well as transit of Notch through defined cellular compartments, including specific endosomes.

A.-C. Tien and A. Rajan contributed equally to this paper.

Abbreviations used in this paper: Avl, Avalanche; Bib, big brain; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; Dx, Deltex; ECD, extracellular domain; EE, early endosome; GOF, gain of function; HD, heterodimer domain; Lfng, Lunatic fringe; Lgd, lethal giant discs; MVB, multivesicular body; NECD, Notch extracellular domain; NEXT, Notch external truncation; NICD, Notch intracellular domain; SCD, spondylocostal dysostosis; T-ALL, T cell acute lymphatic leukemia.

© 2009 Tien et al.
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