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Published online
doi:10.1083/jcb.200812014
The Journal of Cell Biology, Vol. 184, No. 6, 771-776
The Rockefeller University Press, 0021-9525 $30.00
© Pederson et al.
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Mini-Review

In search of nonribosomal nucleolar protein function and regulation



Thoru Pederson1 and Robert Y.L. Tsai2

1 Program in Cell Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605
2 Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030

Correspondence to Robert Y.L. Tsai: rtsai{at}ibt.tamhsc.edu

The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.

Abbreviations used in this paper: APC/C, anaphase-promoting complex or cyclosome; NoLS, nucleolar localization signal; rRNA, ribosomal RNA; SRP, signal recognition particle.

© 2009 Pederson and Tsai
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