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Published online
doi:10.1083/jcb.200811080
The Journal of Cell Biology, Vol. 185, No. 1, 21-26
The Rockefeller University Press, 0021-9525 $30.00
© Dinant et al.
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Assembly of multiprotein complexes that control genome function



Christoffel Dinant1,2, Martijn S. Luijsterburg3, Thomas Höfer4, Gesa von Bornstaedt4, Wim Vermeulen2, Adriaan B. Houtsmuller1, and Roel van Driel3

1 Department of Pathology, Josephine Nefkens Institute and 2 Department of Genetics, Medical Genetics Cluster, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
3 Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, Netherlands
4 German Cancer Research Center, Research Group Modeling of Biological Systems, 69120 Heidelberg, Germany

Correspondence to Roel van Driel: r.vandriel{at}uva.nl

Live-cell imaging studies aided by mathematical modeling have provided unprecedented insight into assembly mechanisms of multiprotein complexes that control genome function. Such studies have unveiled emerging properties of chromatin-associated systems involved in DNA repair and transcription.

© 2009 Dinant et al.
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

M.S. Luijsterburg and C. Dinant contributed equally to this paper.

C. Dinant's present address is Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

M.S. Luijsterburg's present address is Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden.

Abbreviations used in this paper: DSB, double strand break; HR, homologous recombination; NER, nucleotide excision repair; rRNA, ribosomal RNA; TFII, transcription factor II; XP, xeroderma pigmentosum protein.


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