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Mini-Review |
Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane
Correspondence to Ivan R. Nabi: ivan.robert.nabi{at}ubc.ca
The plasma membrane is organized into various subdomains of clustered macromolecules. Such domains include adhesive structures (cellular synapses, substrate adhesions, and cell–cell junctions) and membrane invaginations (clathrin-coated pits and caveolae), as well as less well-defined domains such as lipid rafts and lectin-glycoprotein lattices. Domains are organized by specialized scaffold proteins including the intramembranous caveolins, which stabilize lipid raft domains, and the galectins, a family of animal lectins that cross-link glycoproteins forming molecular lattices. We review evidence that these heterogeneous microdomains interact to regulate substratum adhesion and cytokine receptor dynamics at the cell surface.
P. Lajoie's present address is the Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, NY 10461.
J.G. Goetz's present address is Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid E-28029, Spain.
Abbreviations used in this paper: EGFR, epidermal growth factor receptor; GPI, glycosylphosphatidylinositol; STALL, stimulation-induced temporary arrest of lateral diffusion; TCR, T cell receptor.
© 2009 Lajoie et al.
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
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