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Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06522

Correspondence to Valerie Horsley: valerie.horsley{at}yale.edu

Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811–826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of β-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.

© 2009 Horsley
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