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Published online
doi:10.1083/jcb.200905098
The Journal of Cell Biology, Vol. 185, No. 6, 935-937
The Rockefeller University Press, 0021-9525 $30.00
© Weaver et al.
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The role of aneuploidy in promoting and suppressing tumors



Beth A.A. Weaver1 and Don W. Cleveland2,3

1 Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53562
2 Ludwig Institute for Cancer Research and 3 Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093

Correspondence to Beth A.A. Weaver: baweaver{at}wisc.edu

Impaired mitotic checkpoint signaling can both promote and suppress tumors. The mitotic checkpoint targets Cdc20, the specificity factor of the ubiquitin ligase that promotes anaphase by targeting cyclin B and securin for destruction. In this issue, Li et al. (2009. J. Cell Biol. doi:10.1083/jcb.200904020) use gene replacement to produce mice expressing a Cdc20 mutant that cannot be inhibited by the mitotic checkpoint. In addition to the expected aneuploidy, these animals have a high tumor incidence that is likely caused by persistent aneuploidy coupled with nonmitotic functions of mutant Cdc20.

© 2009 Weaver and Cleveland
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