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Neuronal activity moves protein palmitoylation into the synapse

Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

Correspondence to Matthew B. Dalva: dalva{at}mail.med.upenn.edu

Many neuronal proteins undergo lipid modification that regulates their function and subcellular localization. One such modification is palmitoylation, which is mediated by a large class of protein palmitoyl acyltransferases (PATs). Now, a paper in this issue (Noritake et al. 2009. J. Cell Biol. doi:10.1083/jcb.200903101) demonstrates that the localization of the PAT DHHC2 is regulated by neuronal activity and thereby selectively controls the palmitoylation and subsequent accumulation of specific proteins in the synapse.

© 2009 Dalva
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