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Published online
doi:10.1083/jcb.200907041
The Journal of Cell Biology, Vol. 186, No. 3, 313-315
The Rockefeller University Press, 0021-9525 $30.00
© Latham et al.
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The H2BK123Rgument



John A. Latham and Sharon Y.R. Dent

Program in Genes and Development, Center for Cancer Epigenetics, and Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030

Correspondence to Sharon Y.R. Dent: sroth{at}mdanderson.org

The discovery of trans-regulation of histone H3K4 methylation by ubiquitination of histone H2BK123 generated much excitement in the field of chromatin biology. Recently, the veracity of this example of cross talk between histone modifications in yeast was challenged (Foster and Downs, 2009. J. Cell Biol. doi:10.1083/jcb.200812088) but ultimately reconfirmed in a study in this issue (Nakanishi et al., 2009. J. Cell Biol. doi:10.1083/jcb.200906005).

© 2009 Latham and Dent
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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