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Published online
doi:10.1083/jcb.200906113
The Journal of Cell Biology, Vol. 186, No. 5, 637-644
The Rockefeller University Press, 0021-9525 $30.00
© Bond et al.
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Review

Paraspeckles: nuclear bodies built on long noncoding RNA



Charles S. Bond1 and Archa H. Fox2

1 School of Biomedical, Biomolecular, and Chemical Sciences and 2 Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia

Correspondence to Archa H. Fox: archafox{at}waimr.uwa.edu.au

Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-{epsilon}/β), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.

Abbreviations used in this paper: DBHS, Drosophila melanogaster behavior, human splicing; IGAZ, interchromatin granule–associated zone; ncRNA, noncoding RNA; Pol II, polymerase II; TEM, transmission EM; UTR, untranslated region.

© 2009 Bond and Fox
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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