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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
Correspondence to Sharon A. Tooze: sharon.tooze{at}cancer.org.uk
Autophagy or "self-eating" is a highly conserved pathway that enables cells to degrade pieces of themselves in autolysosomes to enable their survival in times of stress, including nutrient deprivation. The formation of these degradative compartments requires cytosolic proteins, some of which are autophagy specific, as well as intracellular organelles, such as the ER and Golgi, and the endosome–lysosome system. Here we discuss the cross talk between autophagy and intracellular compartments, highlighting recent exciting data about the role and regulation of the Vps34 class III phosphatidylinositol (PI) 3-kinase in autophagy.
Abbreviations used in this paper: Atg, autophagy related; COPI, coat protein complex I; ESCRT, endosomal sorting complex required for transport; IM, isolation membrane; MVB, multivesicular body; PAS, preautophagosomal structure; PI3P, phosphatidylinositol 3-phosphate; ULK, unc-51–like kinase; UVRAG, ultraviolet irradiation resistant–associated gene.
© 2009 Simonsen and Tooze
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
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