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Published online
doi:10.1083/jcb.200909100
The Journal of Cell Biology, Vol. 187, No. 2, 161-163
The Rockefeller University Press, 0021-9525 $30.00
© Lakkaraju et al.
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It takes two to tango to the melanosome



Aparna Lakkaraju1,2, Jose Maria Carvajal-Gonzalez1,2, and Enrique Rodriguez-Boulan1,2,3

1 Margaret M. Dyson Vision Research Institute, 2 Department of Ophthalmology, and 3 Department of Cell and Developmental Biology, Weill Medical College, Cornell University, New York, NY 10065

Correspondence to Enrique Rodriguez-Boulan: boulan{at}med.cornell.edu

The role of clathrin adaptor proteins in sorting cargo in the biosynthetic and recycling routes is an area of intense research. In this issue, Delevoye et al. (2009. J. Cell Biol. doi:10.1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.

© 2009 Lakkaraju et al.
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Related Article

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
Cédric Delevoye, Ilse Hurbain, Danièle Tenza, Jean-Baptiste Sibarita, Stéphanie Uzan-Gafsou, Hiroshi Ohno, Willie J.C. Geerts, Arie J. Verkleij, Jean Salamero, Michael S. Marks, and Graça Raposo
J. Cell Biol. 2009 187: 247-264. [Abstract] [Full Text] [PDF]





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