ARTICLE

EXPERIMENTAL LATHYRISM

Marvin L. Tanzer M.D.¹ and Ronald D. Hunt D.V.M.¹

¹ From the United States Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver.

Dr. Tanzer's present address is Lovett Group, Massachusetts General Hospital, Harvard Medical School, Boston. Dr. Hunt's present address is Animal Research Laboratory, Harvard Medical School, Boston

In normal and lathyritic chick embryos bone collagen was synthesized primarily in the periosteum of the femurs, and was organized as radioactive spicules in these bones. Saline extraction of the lathyritic bones removed the radioactive spicules, although they eventually seemed to become non-extractable. Normal bone seemed to be unaffected by saline extraction. Marked variation in the degree of isotope incorporation was seen in collagenous and non-collagenous tissues. All the tissues of any one embryo, however, showed a similar degree of isotope incorporation. Tritiated ß-aminopropionitrile was diffusely distributed throughout bone and was completely removed by saline extraction. This autoradiographic study supports the postulate that a portion of extractable lathyritic collagen is recently synthesized and is organized in fibrous structures in bone.

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