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The Journal of Cell Biology, Vol 40, 382-388, Copyright © 1969 by Rockefeller University Press

ARTICLE

A DIFFUSIBLE FACTOR WHICH SUSTAINS CONTACT INHIBITION OF REPLICATION



Jen Yeh 1 and Harold W. Fisher 1

1 From the Biophysics Laboratories, University of Rhode Island, Kingston, Rhode Island 02881

Confluent 3T3 cultures make and release into the medium a diffusible factor which sustains the state of contact inhibition of replication. Evidence is given that the factor is a specific and reversible inhibitor of the RNA synthesis which precedes cellular replication.

Submitted on July 30, 1968
Revised on October 2, 1968


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