ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS: II. Ultrastructure of the Beta Granule

doi:10.1083/jcb.41.1.162

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ARTICLE

ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS

: II. Ultrastructure of the Beta Granule

Marie H. Greider ¹, S. L. Howell ¹, and P. E. Lacy ¹

¹ From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

Dr. Howell's present address is the School of Biological Sciences, University of Sussex, Brighton, England

Beta granules isolated from rat islets of Langerhans and subjectedonly to phosphotungstic acid had, in negatively stained images,a 50-A periodicity. This periodicity was also observed in thin-sectionprofiles of beta granules in intact cells. In shadowed preparations,the granules were spherical in shape and had irregular edgesand surface structure. The presence of such a periodicity inthe beta granule indicates that its matrix may be composed ofa crystalline material.

Submitted on August 23, 1968
Revised on November 7, 1968

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