ARTICLE

THE SMOOTH MUSCLE CELL

Russell Ross ¹

¹ Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98105

Smooth muscle derived from the inner media and intima of immature guinea pig aorta were grown for up to 8 wk in cell culture. The cells maintained the morphology of smooth muscle at all phases of their growth in culture. After growing to confluency, they grew in multiple overlapping layers. By 4 wk in culture, microfibrils (110 A) appeared within the spaces between the layers of cells. Basement membrane-like material also appeared adjacent to the cells. Analysis of the microfibrils showed that they have an amino acid composition similar to that of the microfibrillar protein of the intact elastic fiber. These investigations coupled with the radioautographic observations of the ability of aortic smooth muscle to synthesize and secrete extracellular proteins demonstrate that this cell is a connective tissue synthetic cell.

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• Blindt, R., Zeiffer, U., Krott, N., Filzmaier, K., Voss, M., Hanrath, P., vom Dahl, J., Bosserhoff, A.-K. (2002). Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?. Cardiovasc Res 54: 630-639 [Abstract] [Full Text]  
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• Webb, J. G., Yates, P. W., Yang, Q., Mukhin, Y. V., Lanier, S. M. (2001). Adenylyl cyclase isoforms and signal integration in models of vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 281: H1545-H1552 [Abstract] [Full Text]  
• Sun, J.-Z., Oparil, S., Lucchesi, P., Thompson, J. A., Chen, Y.-F. (2001). Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L155-L163 [Abstract] [Full Text]  
• Damon, D. H. (2001). NGF-independent survival of postganglionic sympathetic neurons in neuronal-vascular smooth muscle cocultures. Am. J. Physiol. Heart Circ. Physiol. 280: H1722-H1728 [Abstract] [Full Text]  
• Sironi, L., Calvio, A. M., Arnaboldi, L., Corsini, A., Parolari, A., de Gasparo, M., Tremoli, E., Mussoni, L. (2001). Effect of Valsartan on Angiotensin II-Induced Plasminogen Activator Inhibitor-1 Biosynthesis in Arterial Smooth Muscle Cells. Hypertension 37: 961-966 [Abstract] [Full Text]  
• Okumura, K., Osanai, T., Kosugi, T., Hanada, H., Ishizaka, H., Fukushi, T., Kamada, T., Miura, T., Hatayama, T., Nakano, T., Fujino, Y., Homma, Y. (2000). Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response. J Am Coll Cardiol 36: 1847-1852 [Abstract] [Full Text]  
• Teng, J., Fukuda, N., Hu, W.-Y., Nakayama, M., Kishioka, H., Kanmatsuse, K. (2000). DNA-RNA chimeric hammerhead ribozyme to transforming growth factor-{beta}1 mRNA inhibits the exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats. Cardiovasc Res 48: 138-147 [Abstract] [Full Text]  
• Stepien, O., Marche, P. (2000). Amlodipine inhibits thapsigargin-sensitive CA2+ stores in thrombin-stimulated vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 279: H1220-H1227 [Abstract] [Full Text]  
• Li, G., Chen, Y.-F., Kelpke, S. S., Oparil, S., Thompson, J. A. (2000). Estrogen Attenuates Integrin-{beta}3-Dependent Adventitial Fibroblast Migration After Inhibition of Osteopontin Production in Vascular Smooth Muscle Cells. Circulation 101: 2949-2955 [Abstract] [Full Text]  
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• Hu, W.-Y., Fukuda, N., Satoh, C., Jian, T., Kubo, A., Nakayama, M., Kishioka, H., Kanmatsuse, K. (2000). Phenotypic Modulation by Fibronectin Enhances the Angiotensin II-Generating System in Cultured Vascular Smooth Muscle Cells. Arterioscler. Thromb. Vasc. Bio. 20: 1500-1505 [Abstract] [Full Text]  
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• Baetta, R., Soma, M., De-Fraja, C., Comparato, C., Teruzzi, C., Magrassi, L., Cattaneo, E. (2000). Upregulation and Activation of Stat6 Precede Vascular Smooth Muscle Cell Proliferation in Carotid Artery Injury Model. Arterioscler. Thromb. Vasc. Bio. 20: 931-939 [Abstract] [Full Text]  
• Ying, A. K., Hassanain, H. H., Roos, C. M., Smiraglia, D. J., Issa, J.-P. J., Michler, R. E., Caligiuri, M., Plass, C., Goldschmidt-Clermont, P. J. (2000). Methylation of the estrogen receptor-{alpha} gene promoter is selectively increased in proliferating human aortic smooth muscle cells. Cardiovasc Res 46: 172-179 [Abstract] [Full Text]  
• Nam, T.-J., Busby, W. H. Jr., Rees, C., Clemmons, D. R. (2000). Thrombospondin and Osteopontin Bind to Insulin-Like Growth Factor (IGF)-Binding Protein-5 Leading to an Alteration in IGF-I-Stimulated Cell Growth. Endocrinology 141: 1100-1106 [Abstract] [Full Text]  
• Damon, D. H. (2000). VSM growth is stimulated in sympathetic neuron/VSM cocultures: role of TGF-beta 2 and endothelin. Am. J. Physiol. Heart Circ. Physiol. 278: H404-H411 [Abstract] [Full Text]  
• Scherberich, A, Campos-Toimil, M, Ronde, P, Takeda, K, Beretz, A (2000). Migration of human vascular smooth muscle cells involves serum-dependent repeated cytosolic calcium transients. J. Cell Sci. 113: 653-662 [Abstract]  
• Klouche, M., Bhakdi, S., Hemmes, M., Rose-John, S. (1999). Novel Path to Activation of Vascular Smooth Muscle Cells: Up-Regulation of gp130 Creates an Autocrine Activation Loop by IL-6 and Its Soluble Receptor. J. Immunol. 163: 4583-4589 [Abstract] [Full Text]  
• Li, G., Chen, Y.-F., Greene, G. L., Oparil, S., Thompson, J. A. (1999). Estrogen Inhibits Vascular Smooth Muscle Cell-Dependent Adventitial Fibroblast Migration In Vitro. Circulation 100: 1639-1645 [Abstract] [Full Text]  
• Clemmons, D. R., Horvitz, G., Engleman, W., Nichols, T., Moralez, A., Nickols, G. A. (1999). Synthetic {alpha}V{beta}3 Antagonists Inhibit Insulin-Like Growth Factor-I-Stimulated Smooth Muscle Cell Migration and Replication. Endocrinology 140: 4616-4621 [Abstract] [Full Text]  
• Rufini, S., De Vito, P., Balestro, N., Pescatori, M., Luly, P., Incerpi, S. (1999). PLA2 stimulation of Na+/H+ antiport and proliferation in rat aortic smooth muscle cells. Am. J. Physiol. Cell Physiol. 277: C814-C822 [Abstract] [Full Text]  
• Takaku, M., Wada, Y., Jinnouchi, K., Takeya, M., Takahashi, K., Usuda, H., Naito, M., Kurihara, H., Yazaki, Y., Kumazawa, Y., Okimoto, Y., Umetani, M., Noguchi, N., Niki, E., Hamakubo, T., Kodama, T. (1999). An In Vitro Coculture Model of Transmigrant Monocytes and Foam Cell Formation. Arterioscler. Thromb. Vasc. Bio. 19: 2330-2339 [Abstract] [Full Text]  
• Lau, H. K.F. (1999). Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes. Cardiovasc Res 43: 1049-1059 [Abstract] [Full Text]  
• Veit, K., Boissel, J.-P., Buerke, M., Grosser, T., Meyer, J., Darius, H. (1999). Highly efficient liposome-mediated gene transfer of inducible nitric oxide synthase in vivo and in vitro in vascular smooth muscle cells. Cardiovasc Res 43: 808-822 [Abstract] [Full Text]  
• MASON, C. A. E., CHANG, P., FALLERY, C., RABINOVITCH, M. (1999). Nitric oxide mediates LC-3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formation. FASEB J. 13: 1423-1434 [Abstract] [Full Text]  
• Zancan, V., Santagati, S., Bolego, C., Vegeto, E., Maggi, A., Puglisi, L. (1999). 17{beta}-Estradiol Decreases Nitric Oxide Synthase II Synthesis in Vascular Smooth Muscle Cells. Endocrinology 140: 2004-2009 [Abstract] [Full Text]  
• Fukuda, N., Satoh, C., Hu, W.-Y., Soma, M., Kubo, A., Kishioka, H., Watanabe, Y., Izumi, Y., Kanmatsuse, K. (1999). Production of Angiotensin II by Homogeneous Cultures of Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats. Arterioscler. Thromb. Vasc. Bio. 19: 1210-1217 [Abstract] [Full Text]  
• Woods, M., Mitchell, J. A., Wood, E. G., Barker, S., Walcot, N. R., Rees, G. M., Warner, T. D. (1999). Endothelin-1 Is Induced by Cytokines in Human Vascular Smooth Muscle Cells: Evidence for Intracellular Endothelin-Converting Enzyme. Mol. Pharmacol. 55: 902-909 [Abstract] [Full Text]  
• Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S., Marini, R., Langer, R. (1999). Functional Arteries Grown in Vitro. Science 284: 489-493 [Abstract] [Full Text]  
• Iouzalen, L., Stepien, O., Marche, P. (1999). Effects of Bay 10-6734 (Embusartan), a New Angiotensin II Type I Receptor Antagonist, on Vascular Smooth Muscle Cell Growth. J. Pharmacol. Exp. Ther. 289: 181-187 [Abstract] [Full Text]  
• Fareh, J., Martel, R., Kermani, P., Leclerc, G. (1999). Cellular Effects of ß-Particle Delivery on Vascular Smooth Muscle Cells and Endothelial Cells : A Dose-Response Study. Circulation 99: 1477-1484 [Abstract] [Full Text]  
• Klouche, M., May, A. E., Hemmes, M., Meßner, M., Kanse, S. M., Preissner, K. T., Bhakdi, S. (1999). Enzymatically Modified, Nonoxidized LDL Induces Selective Adhesion and Transmigration of Monocytes and T-Lymphocytes Through Human Endothelial Cell Monolayers. Arterioscler. Thromb. Vasc. Bio. 19: 784-793 [Abstract] [Full Text]  
• Wada, T., McKee, M. D., Steitz, S., Giachelli, C. M. (1999). Calcification of Vascular Smooth Muscle Cell Cultures : Inhibition by Osteopontin. Circ. Res. 84: 166-178 [Abstract] [Full Text]  
• Nickenig, G., Roling, J., Strehlow, K., Schnabel, P., Bohm, M. (1998). Insulin Induces Upregulation of Vascular AT1 Receptor Gene Expression by Posttranscriptional Mechanisms. Circulation 98: 2453-2460 [Abstract] [Full Text]  
• Scherberich, A., Moog, S., Haan-Archipoff, G., Azorsa, D. O., Lanza, F., Beretz, A. (1998). Tetraspanin CD9 Is Associated With Very Late–Acting Integrins in Human Vascular Smooth Muscle Cells and Modulates Collagen Matrix Reorganization. Arterioscler. Thromb. Vasc. Bio. 18: 1691-1697 [Abstract] [Full Text]  
• Chin, T.-Y., Chueh, S.-H. (1998). Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. Am. J. Physiol. Cell Physiol. 275: C1255-C1263 [Abstract] [Full Text]  
• Rees, C., Clemmons, D. R., Horvitz, G. D., Clarke, J. B., Busby, W. H. (1998). A Protease-Resistant Form of Insulin-Like Growth Factor (IGF) Binding Protein 4 Inhibits IGF-1 Actions. Endocrinology 139: 4182-4188 [Abstract] [Full Text]  
• Zheng, B., Clemmons, D. R. (1998). Blocking ligand occupancy of the alpha Vbeta 3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells. Proc. Natl. Acad. Sci. USA 95: 11217-11222 [Abstract] [Full Text]  
• Parker, A., Rees, C., Clarke, J., Busby Jr., W. H., Clemmons, D. R. (1998). Binding of Insulin-like Growth Factor (IGF)-Binding Protein-5 to Smooth-Muscle Cell Extracellular Matrix Is a Major Determinant of the Cellular Response to IGF-I. Mol. Biol. Cell 9: 2383-2392 [Abstract] [Full Text]  
• Kamide, K., Hori, M. T., Zhu, J.-H., Barrett, J. D., Eggena, P., Tuck, M. L. (1998). Insulin-Mediated Growth in Aortic Smooth Muscle and the Vascular Renin-Angiotensin System. Hypertension 32: 482-487 [Abstract] [Full Text]  
• Zhang, J., Jin, N., Liu, Y., Rhoades, R. A. (1998). Hydrogen Peroxide Stimulates Extracellular Signal-regulated Protein Kinases in Pulmonary Arterial Smooth Muscle Cells. Am. J. Respir. Cell Mol. Bio. 19: 324-332 [Abstract] [Full Text]  
• Panek, R. L., Lu, G. H., Dahring, T. K., Batley, B. L., Connolly, C., Hamby, J. M., Brown, K. J. (1998). In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase. J. Pharmacol. Exp. Ther. 286: 569-577 [Abstract] [Full Text]  
• Nickenig, G., Strehlow, K., Roeling, J., Zolk, O., Knorr, A., Bohm, M. (1998). Salt Induces Vascular AT1 Receptor Overexpression In Vitro and In Vivo. Hypertension 31: 1272-1277 [Abstract] [Full Text]  
• Banai, S., Wolf, Y., Golomb, G., Pearle, A., Waltenberger, J., Fishbein, I., Schneider, A., Gazit, A., Perez, L., Huber, R., Lazarovichi, G., Rabinovich, L., Levitzki, A., Gertz, S. D. (1998). PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine. Circulation 97: 1960-1969 [Abstract] [Full Text]  
• Zheng, B., Duan, C., Clemmons, D. R. (1998). The Effect of Extracellular Matrix Proteins on Porcine Smooth Muscle Cell Insulin-like Growth Factor (IGF) Binding Protein-5 Synthesis and Responsiveness to IGF-I. J. Biol. Chem. 273: 8994-9000 [Abstract] [Full Text]  
• Ito, S., Ishimaru, S., Wilson, S. E. (1998). Effect of Coacervated {alpha}-Elastin on Proliferation of Vascular Smooth Muscle and Endothelial Cells. ANGIOLOGY 49: 289-297 [Abstract]  
• Scheller, T., Kraev, A., Skinner, S., Carafoli, E. (1998). Cloning of the Multipartite Promoter of the Sodium-Calcium Exchanger Gene NCX1 and Characterization of Its Activity in Vascular Smooth Muscle Cells. J. Biol. Chem. 273: 7643-7649 [Abstract] [Full Text]  
• Ariyoshi, H., Okahara, K., Sakon, M., Kambayashi, J.-i., Kawashima, S.-i., Kawasaki, T., Monden, M. (1998). Possible Involvement of m-Calpain in Vascular Smooth Muscle Cell Proliferation. Arterioscler. Thromb. Vasc. Bio. 18: 493-498 [Abstract] [Full Text]  
• Richman, J. G., Regan, J. W. (1998). alpha 2-Adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. Am. J. Physiol. Cell Physiol. 274: C654-C662 [Abstract] [Full Text]  
• Damron, D. S., Nadim, H. S., Hong, S. J., Darvish, A., Murray, P. A. (1998). Intracellular translocation of PKC isoforms in canine pulmonary artery smooth muscle cells by ANG II. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L278-L288 [Abstract] [Full Text]  
• Fukuda, N., Hu, W.-Y., Kubo, A., Endoh, M., Kishioka, H., Satoh, C., Soma, M., Izumi, Y., Kanmatsuse, K. (1998). Abnormal Regulation of Transforming Growth Factor-ß Receptors on Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats by Angiotensin II. Hypertension 31: 672-677 [Abstract] [Full Text]  
• Jacot, T. A., Clemmons, D. R. (1998). Effect of Glucose on Insulin-Like Growth Factor Binding Protein-4 Proteolysis. Endocrinology 139: 44-50 [Abstract] [Full Text]  
• L’Heureux, N., Pâquet, S., Labbé, R., Germain, L., Auger, F. A. (1998). A completely biological tissue-engineered human blood vessel. FASEB J. 12: 47-56 [Abstract] [Full Text]  
• Frid, M. G., Aldashev, A. A., Dempsey, E. C., Stenmark, K. R. (1997). Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities. Circ. Res. 81: 940-952 [Abstract] [Full Text]  
• Panek, R. L., Lu, G. H., Klutchko, S. R., Batley, B. L., Dahring, T. K., Hamby, J. M., Hallak, H., Doherty, A. M., Keiser, J. A. (1997). In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor. J. Pharmacol. Exp. Ther. 283: 1433-1444 [Abstract] [Full Text]  
• Obata, H., Hayashi, K.'i., Nishida, W., Momiyama, T., Uchida, A., Ochi, T., Sobue, K. (1997). Smooth Muscle Cell Phenotype-dependent Transcriptional Regulation of the alpha 1 Integrin Gene. J. Biol. Chem. 272: 26643-26651 [Abstract] [Full Text]  
• Major, T. C., Keiser, J. A. (1997). Inhibition of Cell Growth: Effects of the Tyrosine Kinase Inhibitor CGP 53716. J. Pharmacol. Exp. Ther. 283: 402-410 [Abstract] [Full Text]  
• Seewald, S., Nickenig, G., Ko, Y., Vetter, H., Sachinidis, A. (1997). Low density lipoprotein enhances the thrombin-induced growth of vascular smooth muscle cells. Cardiovasc Res 36: 92-100 [Abstract] [Full Text]  
• Liu, G., Espinosa, E., Oemar, B. S., Luscher, T. F. (1997). Bimodal Effects of Angiotensin II on Migration of Human and Rat Smooth Muscle Cells : Direct Stimulation and Indirect Inhibition Via Transforming Growth Factor-ß1. Arterioscler. Thromb. Vasc. Bio. 17: 1251-1257 [Abstract] [Full Text]  
• Ko, F. N. (1997). Low-Affinity Thromboxane Receptor Mediates Proliferation in Cultured Vascular Smooth Muscle Cells of Rats. Arterioscler. Thromb. Vasc. Bio. 17: 1274-1282 [Abstract] [Full Text]  
• Hutchinson, H. G, Trindade, P. T, Cunanan, D. B, Wu, C.-F., Pratt, R. E (1997). Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells. Cardiovasc Res 35: 158-167 [Abstract] [Full Text]  
• Bhunia, A. K., Han, H., Snowden, A., Chatterjee, S. (1997). Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells. J. Biol. Chem. 272: 15642-15649 [Abstract] [Full Text]  
• Raiteri, M., Arnaboldi, L., Mcgeady, P., Gelb, M. H., Verri, D., Tagliabue, C., Quarato, P., Ferraboschi, P., Santaniello, E., Paoletti, R., Fumagalli, R., Corsini, A. (1997). . J. Pharmacol. Exp. Ther. 281: 1144-1153 [Abstract] [Full Text]  
• Dahring, T. K., Lu, G. H., Hamby, J. M., Batley, B. L., Kraker, A. J., Panek, R. L. (1997). . J. Pharmacol. Exp. Ther. 281: 1446-1456 [Abstract]  
• Sirois, M. G., Simons, M., Edelman, E. R. (1997). Antisense Oligonucleotide Inhibition of PDGFR-ß Receptor Subunit Expression Directs Suppression of Intimal Thickening. Circulation 95: 669-676 [Abstract] [Full Text]  
• Nickenig, G., Sachinidis, A., Michaelsen, F., Bohm, M., Seewald, S., Vetter, H. (1997). Upregulation of Vascular Angiotensin II Receptor Gene Expression by Low-Density Lipoprotein in Vascular Smooth Muscle Cells. Circulation 95: 473-478 [Abstract] [Full Text]  
• Magnier-Gaubil, C., Herbert, J.-M., Quarck, R., Papp, B., Corvazier, E., Wuytack, F., Levy-Toledano, S., Enouf, J. (1996). Smooth Muscle Cell Cycle and Proliferation. RELATIONSHIP BETWEEN CALCIUM INFLUX AND SARCO-ENDOPLASMIC RETICULUM Ca2+ATPase REGULATION. J. Biol. Chem. 271: 27788-27794 [Abstract] [Full Text]  
• Koyama, H., Nishizawa, Y., Hosoi, M., Fukumoto, S., Kogawa, K., Shioi, A., Morii, H. (1996). The Fumagillin Analogue TNP-470 Inhibits DNA Synthesis of Vascular Smooth Muscle Cells Stimulated by Platelet-Derived Growth Factor and Insulin-like Growth Factor-I: Possible Involvement of Cyclin-Dependent Kinase 2. Circ. Res. 79: 757-764 [Abstract] [Full Text]  
• Vijayagopal, P., Glancy, D. L. (1996). Macrophages Stimulate Cholesteryl Ester Accumulation in Cocultured Smooth Muscle Cells Incubated With Lipoprotein-Proteoglycan Complex. Arterioscler. Thromb. Vasc. Bio. 16: 1112-1121 [Abstract] [Full Text]  
• Shirk, R. A., Church, F. C., Wagner, W. D. (1996). Arterial Smooth Muscle Cell Heparan Sulfate Proteoglycans Accelerate Thrombin Inhibition by Heparin Cofactor II. Arterioscler. Thromb. Vasc. Bio. 16: 1138-1146 [Abstract] [Full Text]  

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