ARTICLE

DEXTRANS AND GLYCOGENS AS PARTICULATE TRACERS FOR STUDYING CAPILLARY PERMEABILITY

¹ From The Rockefeller University, New York 10021.

Dr. Simionescu's permanent address is Institute of Endocrinology, Bucharest, Romania

Commercially available glycogens and dextrans can be used as biological particulate tracers in work on capillary permeability. These polysaccharides are well tolerated in intravenous injection and induce no vascular leakage when applied topically (cremaster test) in mice and in Wistar-Furth rats. The particles stain adequately with lead after aldehyde-OsO₄ fixation in phosphate buffer and provide a relatively wide set of probes (45 A-300 A) for work on the large and small pore systems.

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