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The Journal of Cell Biology, Vol 50, 787-794, Copyright © 1971 by Rockefeller University Press

ARTICLE

TURNOVER OF HELA RIBOSOMAL RNA

: The Characterization of a Class of RNA in HeLa Cytoplasm Derived from 28S RNA



C. N. Nair 1 and E. Knight Jr. 1

1 From the Central Research Department, Experimental Station, E. I. du Pont de Nemours and Company, Wilmington, Delaware 19898.

Dr. Nair's present address is the Department of Health Sciences, East Tennessee State University, Johnson City, Tennessee 37601

A class of RNA in HeLa cytoplasm with a sedimentation value of 22S is described. This RNA is a true cytoplasmic component and is not an artifact of cell rupture or of the method of RNA preparation. The 22S RNA sediments in a sucrose gradient with those ribosomal structures containing 28S ribosomal RNA (60S and 74S particles and polyribosomes). It has a base composition and methyl content similar to those of 28S RNA. The kinetics of formation of 22S suggest that it is not a direct product of transcription but is derived in vivo from "old" molecules of 28S RNA.

Submitted on December 11, 1970
Revised on March 25, 1971


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