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The Journal of Cell Biology, Vol 60, 460-472, Copyright © 1974 by Rockefeller University Press

ARTICLE

CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES

: Demonstration of Membrane-Specific Autoantigens



David H. DeHeer 1, Merle S. Olson 1, and R. Neal Pinckard 1

1 From the Departments of Microbiology and Biochemistry, University of Arizona College of Medicine, Tucson, Arizona 85724.

Dr. DeHeer's present address is the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.

Submitted on June 25, 1973
Revised on October 29, 1973


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