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The Journal of Cell Biology, Vol 61, 359-368, Copyright © 1974 by Rockefeller University Press

ARTICLE

RAPID CHANGES IN NUCLEOSIDE TRANSPORT INDUCED BY GROWTH INHIBITORS

: Studies with Neoplastic Mast Cells



Clifford A. Lingwood 1 and D. Brian Thomas 1

1 From the Department of Immunology, Middlesex Hospital Medical School, London, England

Aqueous extracts of murine embryonic or uterine tissue, or [6N]O2'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble material. However, these alterations were not a consequence of growth arrest. Different dose-response curves were obtained for cytostasis and inhibition of [3H]-nucleoside incorporation, and changes in [3H]thymidine uptake were detected within 15 min of treatment with the inhibitors. Also, there were differential effects of each inhibitor on the incorporation of 3H-labeled thymidine, uridine, adenosine, or choline into acid-insoluble material.

Submitted on September 19, 1973
Revised on January 7, 1973


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