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The Journal of Cell Biology, Vol 70, 714-719, Copyright © 1976 by The Rockefeller University Press

ARTICLES

Fibrils attached to the nuclear pore prevent egress of SV40 particles from the infected nucleus

GG Maul

SV40 particles can apparently enter the nucleus intact. However, they do not leave the nucleus despite the high concentration present during the productive phase. We found structural evidence that SV40 virus is prevented from approaching the most likely site of exit, the nuclear pore complex. From these images, it is concluded that the fibrils attached to the nuclear pore complex prevent egress of SV40 particles from the infected nucleus.
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