Loss and reappearance of gap junctions in regenerating liver

doi:10.1083/jcb.78.2.554

This Article

	Full Text (PDF, 5419K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Yee, A. G.
	Articles by Revel, J. P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Yee, A. G.
	Articles by Revel, J. P.


Social Bookmarking

	What's this?

ARTICLES

Loss and reappearance of gap junctions in regenerating liver

AG Yee and JP Revel

Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered. Between 0 and 20 h after partial hepatectomy, the junctions appeared virtually unchanged. 28 h after partial hepatectomy, however, the large gap junctions usually located close to the bile canaliculi and the small gap junctions enmeshed within the strands of the zonulae occudentes completely disappeared. Although the zonulae occludentes bordering the bile canaliculi apparently remained intact, numerous strands could now be found oriented perpendicular to the canaliculi. In some instances, the membrane outside the canaliculi was extensively filled with isolated junctional strands, often forming very complex configurations. About 40 h after partial hepatectomy, very many small gap junctions reappeared in close association with the zonulae occludentes. Subsequently, gap junctions increased in size and decreased in number until about 48 h after partial hepatectomy when gap junctions were indistinguishable in size and number from those of control animals. The zonulae occludentes were again predominantly located around the canalicular margins. These studies provide further evidence for the growth of gap junctions by the accretion of particles and of small gap junctions to form large maculae.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Carson, J. L., Reed, W., Moats-Staats, B. M., Brighton, L. E., Gambling, T. M., Hu, S.-c., Collier, A. M. (1998). Connexin 26�Expression in Human and Ferret Airways and Lung During Development. Am. J. Respir. Cell Mol. Bio. 18: 111-119 [Abstract] [Full Text]
Xie, H.-q., Laird, D. W., Chang, T.-H., Hu, V. W. (1997). A Mitosis-specific Phosphorylation of the Gap Junction Protein Connexin43 in Human Vascular Cells: Biochemical Characterization and Localization. JCB 137: 203-210 [Abstract] [Full Text]
Fujimoto, K, Nagafuchi, A, Tsukita, S, Kuraoka, A, Ohokuma, A, Shibata, Y (1997). Dynamics of connexins, E-cadherin and alpha-catenin on cell membranes during gap junction formation. J. Cell Sci. 110: 311-322 [Abstract]
Kriegstein, A. R. (1995). Cell-Cell Signaling in Early Cortical Development. Neuroscientist 1: 268-276 [Abstract]
Kojima, T, Mitaka, T, Paul, D., Mori, M, Mochizuki, Y (1995). Reappearance and long-term maintenance of connexin32 in proliferated adult rat hepatocytes: use of serum-free L-15 medium supplemented with EGF and DMSO. J. Cell Sci. 108: 1347-1357 [Abstract]
Albright, C. D., Jones, R. T., Grimley, P. M., Resau, J. H. (1990). Intercellular Communication in Bronchial Epithelial Cells: Review of Evidence for a Possible Role in Lung Carcinogenesis. Toxicol Pathol 18: 324-343 [Abstract]
Revel, J.-P., Nicholson, B. J., Yancey, S. B. (1982). Partial Sequence and Turnover of Rat Liver Gap Junction Protein. Cold Spring Harb Symp Quant Biol 46: 633-637 [Abstract]