Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen

doi:10.1083/jcb.84.3.767

This Article

	Full Text (PDF, 1036K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Salzer, J. L.
	Articles by Glaser, L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Salzer, J. L.
	Articles by Glaser, L.


Social Bookmarking

	What's this?

ARTICLES

Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen

JL Salzer, RP Bunge and L Glaser

In the preceding paper (Salzer et al., 1980, J. Cell Biol. 84:753-- 766), evidence was presented that a neurite membrane fraction could be used to stimulate Schwann cell proliferation in culture. In this study, we present evidence that the mitogenic signal by which intact neurites or neurite membranes stimulate Schwann cell proliferation is located at the neurite surface. This conclusion is based on the following observations: (a) stimulation of Schwann cell proliferation by neurons requires direct contact between neurites and Schwann cells, separation of the two cells by a permeable collagen diaphragm 6 microns thick prevents Schwann cell proliferation; (b) treatment of intact neurites with trypsin before preparation of neurite membranes abolishes the ability of these membranes to be mitogenic for Schwann cells; and (c) the mitogenic activity of neurite homogenates is exclusively localized in the particulate rather than the soluble fraction of the homogenate. The mitogenic component on the neurite surface is heat labile, and is inactivated by aldehyde fixation. Preliminary data suggest that the mitogenic effect of neurite on Schwann cells is not mediated by 3',5'- cyclic AMP.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Yu, W.-M., Chen, Z.-L., North, A. J., Strickland, S. (2009). Laminin is required for Schwann cell morphogenesis. J. Cell Sci. 122: 929-936 [Abstract] [Full Text]
Rosenberg, S. S., Kelland, E. E., Tokar, E., De La Torre, A. R., Chan, J. R. (2008). From the Cover: The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation. Proc. Natl. Acad. Sci. USA 105: 14662-14667 [Abstract] [Full Text]
McClatchey, A. I., Giovannini, M. (2005). Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. Genes Dev. 19: 2265-2277 [Abstract] [Full Text]
Hall, S. (2005). The response to injury in the peripheral nervous system. J Bone Joint Surg Br 87-B: 1309-1319 [Full Text]
Murinson, B. B., Archer, D. R., Li, Y., Griffin, J. W. (2005). Degeneration of Myelinated Efferent Fibers Prompts Mitosis in Remak Schwann Cells of Uninjured C-Fiber Afferents. J. Neurosci. 25: 1179-1187 [Abstract] [Full Text]
Wanner, I. B., Wood, P. M. (2002). N-Cadherin Mediates Axon-Aligned Process Growth and Cell-Cell Interaction in Rat Schwann Cells. J. Neurosci. 22: 4066-4079 [Abstract] [Full Text]
Zanazzi, G., Einheber, S., Westreich, R., Hannocks, M.-J., Bedell-Hogan, D., Marchionni, M. A., Salzer, J. L. (2001). Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination. JCB 152: 1289-1300 [Abstract] [Full Text]
Chan, J. R., Rodriguez-Waitkus, P. M., Ng, B. K., Liang, P., Glaser, M. (2000). Progesterone Synthesized by Schwann Cells during Myelin Formation Regulates Neuronal Gene Expression. Mol. Biol. Cell 11: 2283-2295 [Abstract] [Full Text]
Maurel, P., Salzer, J. L. (2000). Axonal Regulation of Schwann Cell Proliferation and Survival and the Initial Events of Myelination Requires PI 3-Kinase Activity. J. Neurosci. 20: 4635-4645 [Abstract] [Full Text]
Howe, D. G., McCarthy, K. D. (2000). Retroviral Inhibition of cAMP-Dependent Protein Kinase Inhibits Myelination But Not Schwann Cell Mitosis Stimulated by Interaction with Neurons. J. Neurosci. 20: 3513-3521 [Abstract] [Full Text]
Stevens, B., Tanner, S., Fields, R. D. (1998). Control of Myelination by Specific Patterns of Neural Impulses. J. Neurosci. 18: 9303-9311 [Abstract] [Full Text]
Love, F. M., Thompson, W. J. (1998). Schwann Cells Proliferate at Rat Neuromuscular Junctions during Development and Regeneration. J. Neurosci. 18: 9376-9385 [Abstract] [Full Text]
Schroering, A., Carey, D. J. (1998). Sensory and Motor Neuron-derived Factor Is a Transmembrane Heregulin That Is Expressed on the Plasma Membrane with the Active Domain Exposed to the Extracellular Environment. J. Biol. Chem. 273: 30643-30650 [Abstract] [Full Text]
Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B., Carey, D. J. (1998). Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin. Mol. Cell. Biol. 18: 6245-6252 [Abstract] [Full Text]
Friedman, H. C.�H., Jelsma, T. N., Bray, G. M., Aguayo, A. J. (1996). A Distinct Pattern of Trophic Factor Expression in Myelin-Deficient Nerves of Trembler Mice: Implications for Trophic Support by Schwann Cells. J. Neurosci. 16: 5344-5350 [Abstract] [Full Text]
Mahanthappa, N. K., Anton, E. S., Matthew, W. D. (1996). Glial Growth Factor 2,�a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth. J. Neurosci. 16: 4673-4683 [Abstract] [Full Text]
Ambros, I. M., Zellner, A., Roald, B., Amann, G., Ladenstein, R., Printz, D., Gadner, H., Ambros, P. F. (1996). Role of Ploidy, Chromosome 1p, and Schwann Cells in the Maturation of Neuroblastoma. NEJM 334: 1505-1511 [Abstract] [Full Text]
Becker, T., Bothe, G, Berliner, A., Macagno, E. (1996). Identified central neurons convey a mitogenic signal from a peripheral target to the CNS. Development 122: 2331-2337 [Abstract]
Friedman, B., Wong, V., Lindsay, R. M. (1995). Review : Axons, Schwann Cells, and Neurotrophic Factors. Neuroscientist 1: 192-199 [Abstract]
Selzer, M. E. (1995). Mechanisms of Functional Recovery in Traumatic Brain Injury. Neurorehabil Neural Repair 9: 73-82
Bhattacharyya, A, Brackenbury, R, Ratner, N (1994). Axons arrest the migration of Schwann cell precursors. Development 120: 1411-1420 [Abstract]
Brockes, J. (1984). Mitogenic growth factors and nerve dependence of limb regeneration. Science 225: 1280-1287 [Abstract]
Wang, J. Y., Miller, S. J., Falls, D. L. (2001). The N-terminal Region of Neuregulin Isoforms Determines the Accumulation of Cell Surface and Released Neuregulin Ectodomain. J. Biol. Chem. 276: 2841-2851 [Abstract] [Full Text]