An endothelial cell-derived growth factor

doi:10.1083/jcb.85.2.467

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An endothelial cell-derived growth factor

C Gajdusek, P DiCorleto, R Ross and SM Schwartz

Cell-free plasma-derived serum (PDS) is deficient in the platelet- derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex.
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