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The Journal of Cell Biology, Vol 86, 1-5, Copyright © 1980 by The Rockefeller University Press

ARTICLES

Association of creatine phosphokinase with the cytoskeleton of cultured mammalian cells

BS Eckert, SJ Koons, AW Schantz and CR Zobel

Using an antibody specific for creatine phosphokinase (CPK), we have discovered an association between that enzyme and the cytoskeleton. Immunofluorescence observations show that CPK is associated with intermediate filaments in PTK cells and BALB/3T3 cells. The CPK distribution also follows intermediate filaments when cells are treated with colchicine.
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