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The Journal of Cell Biology, Vol 94, 483-488, Copyright © 1982 by The Rockefeller University Press

ARTICLES

Localization of an Ia-bearing glomerular cell in the mesangium

GF Schreiner and RS Cotran

Using trypsin to render intact, isolated rat glomeruli permeable to antibody, and using an electron microscopic immunoperoxidase technique, we have localized a phagocytic immunologically-relevant cell bearing Ia determinants to the renal mesangium. Thus there are at least two functionally distinct cell types in the renal mesangium: one is a contractile smooth musclelike cell, and the other a phagocytic cell that bears immunologically-relevant surface determinants.
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