Figure 5 Fibrin(ogen) deposition increases after sciatic nerve injury and correlates with axonal degeneration and demyelination. Staining of parallel sections of a partially crushed wild-type sciatic nerve 8 d after injury with Oil Red O (A), a myelin stain, and antifibrinogen antibody (B) revealed that the crushed part of the nerve, which underwent axonal degeneration (A, Oil Red O stained aggregates represent myelin debris accumulation), also had extensive deposition of fibrin(ogen) (B), whereas the immediately adjacent, uninjured region was free of fibrin(ogen). Double-headed arrows indicate uninjured and crushed regions. Bar, 165 µm.