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Published online 3 June 2002. doi:10.1083/jcb1576iti2
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© The Rockefeller University Press, 0021-9525/2002/6/905 $5.00
The Journal of Cell Biology, Volume 157, Number 6, June 10, 2002 905-905

In This Issue

A vitamin makes minerals


Vitamin A induces bone mineralization.

Growth plate chondrocytes help turn cartilage into bone by releasing specialized matrix vesicles, which contain the crystaline seeds for calcification. On page 1061, Wang and Kirsch show how retinoic acid (vitamin A) controls this process of mineralization.

Previous work showed that retinoic acid stimulates mineralization and induces the formation of matrix vesicles, but its molecular targets remained unknown. In the new study, the authors found that, in cultured growth plate chondrocytes, retinoic acid acts by increasing the transcription of three annexin family proteins and causing them to form calcium channels in the plasma membrane.

Retinoic acid is known to regulate transcription after binding to the retinoic acid receptor complex, but the new results imply that it can also control calcium homeostasis, perhaps through receptors yet to be discovered. After retinoic acid induces an initial calcium influx, the formation of induced annexins into channels in the plasma membrane further boosts cytosolic calcium, increasing annexin expression again and causing the release of matrix vesicles. These vesicles contain annexin channels that allow the entry of crystal-forming calcium.

Excess mineralization has been implicated in several disease processes, including osteoarthritis and the calcification of cardiovascular tissues. Recently, the authors have determined that annexin expression is induced in osteoarthritic chondrocytes. If annexins are as central to pathogenic mineralization as they appear to be in healthy tissue, they could be promising targets for a variety of therapies. {blacksquare}



Alan W. Dove

alanwdove{at}earthlink.net


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Related Article

Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization
Wei Wang and Thorsten Kirsch
J. Cell Biol. 2002 157: 1061-1070. [Abstract] [Full Text] [PDF]




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