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© The Rockefeller University Press, 0021-9525/2003/5/455-b $5.00
The Journal of Cell Biology, Volume 161, Number 3, 455-b-455

The neutrophil as firefighter

Transendothelial migration of neutrophils affects the localization of NFB in endothelial cells.

Severe bacterial infection or trauma frequently leads to a systemic inflammatory response, a self-reinforcing activation of neutrophils and vascular endothelial cells that can be deadly. On page 641, Cepinskas et al. describe a neutrophil-mediated signaling mechanism that inhibits inflammation. The findings demonstrate a novel function for neutrophils and a previously unknown form of immunological tolerance, and they identify a promising target for new anti-inflammatory drugs.

In systemic inflammation, circulating cytokines cause the transcription factor NFB to translocate from the cytoplasm to the nucleus of vascular endothelial cells, where it induces the transcription of pro-inflammatory genes. Using a cell culture model of inflammation, the authors found that the migration of neutrophils across a monolayer of cytokine-activated endothelial cells causes NFB levels in the endothelial cell nuclei to drop. Cross-linking the adhesion molecule PECAM-1 on the surface of the endothelial cells produces the same effect, suggesting that the neutrophils send anti-inflammatory signals to the endothelium through PECAM-1. Exposing the neutrophil-calmed endothelial cells to a second round of cytokine activation results in even further reduction of the pro-inflammatory response. The authors are now trying to determine what controls this novel type of induced tolerance at the molecular level.

Alan W. Dove

alanwdove{at}earthlink.net

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PMN transendothelial migration decreases nuclear NFB in IL-1ß–activated endothelial cells: role of PECAM-1

Gediminas Cepinskas, Jurate Savickiene, Carmen V. Ionescu, and Peter R. Kvietys
J. Cell Biol. 2003 161: 641-651. [Abstract] [Full Text] [PDF]

This Article Full Text (PDF, 739K) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dove, A. W. Search for Related Content PubMed Articles by Dove, A. W. Related Collections Related Article Social Bookmarking                            What's this?